Antiepileptic drugs (AEDs) are the main line of the treatment to prevent seizure recurrence, influencing all aspects of women's experiences of having a child: from preconception, pregnancy and labour, to the postnatal stage and infant care. Major malformations, like congenital heart disease, neural tube defects, urogenital defects and cleft lips or palates, occur in about 3-7% of women with epilepsy who take antiepileptic drugs. GTCSs can cause maternal or fetal hypoxia and acidosis; in addition, GTCSs have been associated with fetal intracranial hemorrhages, miscarriages and stillbirths. The mono therapy was PB, MPB, VPA, CBZ, PHT and polytherapy was VPA+ PB, VPA+ MPB and VPA+ CBZ. Infants with cardiac malformation due to PB, VPA; infants with defect of oral cleft due to PB, MPA; hypospadias due to VPA, marginally with PB; porencephalopathy, multiple cysts, anomalies of brain due to VPA; microstomia, microcheilia and congenital anomalies of face due to VPA; circulatory system associated between left superior vena cava and other anomalies of circulatory system is due to PB. AED polytherapy confers a higher risk of major malformations and neuro developmental delay than does AED monotherapy regimens.
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